People With Allergic Conditions – Such As Hay Fever and Eczema – May Have a Lower Risk of COVID-19 Infection

Age, male gender, and other medical conditions not associated with increased risk….Unlike Asian ethnicity, obesity, overcrowding, sociability, and the roles people face.

People suffering from allergic conditions such as hay fever, rhinitis, and atopy eczemaThey may have less risk COVID-19 Infections, especially if they also have asthma, finds a large population-based study of adults in the UK, published online in the journal Respiratory the chest.

The research notes that, contrary to the findings of recent studies, advanced age, male gender and other underlying conditions are not associated with an increased risk of infection.

The results showed that Asian ethnicity, obesity, family overcrowding, social contact within the home with other families, and stress on a role people face other than health and social care were all independently associated with an increased risk of COVID-19.

A growing body of evidence suggests that at least some of the risk factors for developing COVID-19 may differ from those that lead to severe illness and the need for intensive care, researchers say.

To further explore this and learn about the contribution of demographic, socioeconomic, lifestyle, diet, medical treatment and underlying conditions that may lead to the risk of contracting COVID-19, the researchers obtained detailed information about potential risk factors for infection among UK adults between May 2020. and February 2021.

All participants were asked to provide information on their age, family circumstances, occupation, lifestyle, weight, height, long-term medical conditions, medication use, vaccination status, diet, and supplement intake when they joined the study and then again in subsequent months.

Of 16,081 eligible subjects, 15,227 completed at least one monthly follow-up questionnaire 30 or more days after joining the study; and 14,348 completed the final survey on or before February 5, 2021.

The average age of the participants was 59; 70 percent of women; And 95% identified their ethnicity as being white.

In all, 446 participants (approximately 3%) had at least one episode of confirmed COVID-19 infection, as determined by swab testing (PCR or lateral flow) during the study period, and 32 were hospitalized.

The researchers accounted for a range of potential influencing factors: age: gender: duration of study participation: ethnicity: test frequency: ethnicity; education; deprivation of family income; type of housing; number of people per bedroom; Schoolchildren at home shielding pet dog ownership. socialization with other families; visiting shops and other indoor public places; travel for work or study; the status of the front-line worker; physical activity; alcohol intake; weight (body mass index); crisis; Allergy. use of immunosuppressive drugs, inhaled corticosteroids and bronchodilators; BCG vaccination status; eating fruits, vegetables and salad; And the use of nutritional supplements.

Thus certain factors emerged as independently associated with increased odds of contracting COVID-19.

People of British Asian/Asian descent were more likely to develop infections than their white counterparts.

Likewise, household overcrowding; socialization with other families in the previous week; number of visits to indoor public places; a role facing people other than health and social care; And being overweight/obese are all associated with an increased risk.

The results showed that the more people shared a household, and the more visits to indoor public spaces were, the higher the odds of infection.

But atopic disease (caused by an allergen), which includes eczema/dermatitis and hay fever/allergic rhinitis, was independently associated with a 23% lower odds of developing an infection compared to those without atopic disease or asthma.

And among those with atopic disease and asthma, the risk was lower: 38%. This relationship was validated even after accounting for factors of steroid inhaler use.

The researchers said that taking medications to suppress the immune system’s response (immunosuppressants) was also associated with a 53% lower odds of contracting COVID-19 infection, although this may reflect greater protection from infection by these patients.

But age, gender, other medical conditions, diet and supplement use were not associated with risk.

This is an observational study, and as such, cannot prove cause. The researchers acknowledge some limitations to their study.

These include a lack of control over the swab test and reliance on results of routine tests that are usually symptom-driven, so those with asymptomatic infections are likely to miss.

Participants also volunteered themselves, so some ethnic minorities, especially black, African and Caribbean people, were underrepresented in the study.

However, the researchers concluded: “This large, prospective, population-based study shows that there is limited overlap between risk factors for developing COVID-19 versus those for ICU admission and death, as reported in the hospital cohort.”

Reference: “Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK)” by Hayley Holt, Muhammad Talay, Matthew Greene, Dominic Zener, Jane Simmons, Claire Rilton, Catherine S. Young, Molly R Davies, Kathryn N. Thompson , Jade Ashman, Sultan Saeed Rajput, Ahmed Ali Kayali, Sarah Al-Rifai, Philippa G Lloyd, David Gulevi, Olivia Themis, Sarah Viner, Stamatina Iliodromiti, Alec Miners, Nicholas Hopkinson, Bodroll Alam, Graham Lloyd Jones, Thomas Dietrich, and Ian Chapel, Paul E. Pfeiffer, David McCoy, Gwyneth Davis, Ronan A. Lyons, Christopher Griffiths, Frank Key, Aziz Sheikh, Jerome Brin, Seif O. Shaheen and Adrian R. Martino, November 30, 2021, 2021 the chest.
DOI: 10.1136 / Thoraxjnl-2021-217487

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